The fraternity has been long associated with the ALS Association (ALSA) because of Lou Gehrig, an alumnus who died of the disease. Amytrophic lateral sclerosis (ALS) is a debilitating neuro-muscular disease and has since become known as Lou Gehrig's disease. Although there had always existed a relationship between ALSA and Phi Delta Theta, it was not until November 2002 that the General Council made the partnership official. Undergraduate and alumni chapters from all across North America regularly organize events to raise money for research. In August 2017, Phi Delta Theta terminated its partnership with ALSA and elected to proceed with creating their own ALS-related charity. But now they have elected to work closely with the LiveLikeLou Foundation to succeed in leaving ALS better than they found it.